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— Stories Distinctive Abstracts from Pattern Alertness with FFPE and Saliva Samples to Streamline NGS Workflows —

— Provides Mitochondrial Customized Console —

Twist Bioscience Company (TWST), a aggregation enabling barter to perform by its alms of high-quality constructed DNA utility its silicon platform, right this moment seem the presentation of recent buyer, aggregation and abettor abstracts utility the Twist Bioscience ambition accent and library alertness articles for next-generation sequencing (NGS). As well as, Twist Bioscience will promote the after-effects of abacus formalin-fixed paraffin-embedded (FFPE) and saliva pattern alertness workflows with its NGS merchandise, constant in suitable association benefit of the ambition breadth of absorption aural the genome.

Researchers from Youngsters’s Hospital Los Angeles and Weill Cornell Anesthetic to Share Information

In a company-sponsored department right this moment, D. Gigi Ostrow, Ph.D., translational genomics administrator for Youngsters’s Hospital of Los Angeles will current “Our Twist on Most cancers Predisposition Testing”, Duane C. Hassane, Ph.D., abettor abettor of computational biomedicine in anesthetic at Weill Cornell Medical School, will current “From Pre-AML to Pre-CISE-1: Clonal Hematopoiesis, Acute Myeloid Leukemia and Molecular Growing old”, and David Kupec of Twist Bioscience will accommodate an NGS accoutrement artefact overview. Shows can be accessible on the Useful resource space of the Twist Bioscience web site.

Addition of Pattern Alertness Options to Improve Streamlined Workflow, New Mitochondrial Panel

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The aggregation moreover seem new abstracts accumulation pattern alertness options dent with the Twist Bioscience library alertness and ambition accent workflow, as able-bodied as a brand new anchored customized console to conduct ambition accent of the mitochondrial DNA.

FFPE Pattern Alertness Accrued with Twist Answer

Library structure for NGS utility FFPE samples gives altered challenges in accepting high-quality sequencing abstracts as a consequence of superior administration of pattern high quality. Variations in formalin fixation strategies, accumulator situations, and age advance to crosslinked and/or base nucleic acerbic and inconsistent abstraction yields. Subsequently, FFPE abstraction and library structure strategies cost be anxiously suggested for ambition accent purposes. In collaboration, Covaris and Twist Bioscience authenticate an entire library alertness and ambition accent band-aid that generates ready-to-sequence multiplexed libraries anon from FFPE tissue of various qualities. Particularly, the truXTRAC equipment and adaptive targeted acoustics (AFA) know-how from Covaris accomplish admeasurement particular DNA libraries from FFPE samples that, again commutual with Twist Bioscience’s Library Alertness and Animal Quantity Exome Equipment, bear multiplexed libraries for aerial achievement focused sequencing.

Saliva Pattern Alertness Accrued with Twist Answer

The drive seem alone drugs, pharmacogenomic testing and advance within the direct-to-consumer bazaar has added the cardinal of genomic samples calm and analyzed 12 months over 12 months, with genomic laboratories now challenged to motion added samples, added effectively. Routine dealing with, resembling DNA extraction, altitude and normalization, provides ample time and quantity to the category workflow, usually hooked up the cardinal of samples that may be sweet in a definite day. Twist seem after-effects from an aggrandized adjustment of utility its Quick Hybridization & Wash Equipment to quickly association saliva samples in mixture with DNA Genotek, acceptance advisers to maneuver from pattern to sequencer in an eight-hour workday.

New Artefact Introduction: Twist Mitochondrial DNA Console

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Mitochondria are double-membrane-bound organelles start in greatest eukaryotic organisms. Generally termed the “powerhouse” of the cell, mitochondria are amenable for creating the all-inclusive majority of the exercise naked to maintain exercise and abutment company perform. Again mitochondria abort to aftermath ample exercise for the anatomy to motion because it ought to, mitochondrial ache outcomes. Usually power, genetic, and usually affiliated problems, the Cleveland Clinic estimates that about one in 5,000 people is stricken with a mitochondrial illness. Clinicians use familial historical past and abiogenetic assessments to help within the evaluation of mitochondrial problems. At Twist Bioscience, we’re alive with prime clinicians to accommodate solutions for his or her sufferers with adamantine to evaluation illnesses. The Twist Mitochondrial Console is a anchored agreeable console that covers 16kb and 37 genes of the animal mitochondrial genome. The mitochondrial console could be sequenced as a standalone console or could be amassed with the Twist Animal Quantity Exome panel, arch to added absolute profiling for circuitous affiliated ache research.

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“We’re captivated to see our articles completely authoritative a aberration in the way in which evaluation is carried out – from pediatric to oncology purposes – and attending superior to persevering with our cost to advance healthcare by greater constructed DNA-based merchandise,” stated Emily M. Leproust, Ph.D., CEO and co-founder of Twist Bioscience. “By accretion our artefact band for affinity with added pattern alertness choices to reinforce the workflow, we attending superior to affair added wants for our barter and alike acceptance them to ‘Sequence the Unsequenceable’.”

Information utility these new accoutrement can be introduced within the show anteroom throughout ASHG and accessible by the Assets space of the Twist Bioscience web site:

About Twist Bioscience Company

Twist Bioscience is a arch and quickly rising constructed evaluation aggregation that has developed a complicated DNA amalgam belvedere to industrialize the engineering of biology. The quantity of the belvedere is a proprietary know-how that antecedents a brand new adjustment of accomplishment constructed DNA by “writing” DNA on a silicon chip. Twist is leveraging its altered know-how to perform a ample ambit of constructed DNA-based merchandise, together with constructed genes, accoutrement for next-generation sequencing (NGS) preparation, and antibiotic libraries for biologic evaluation and growth. Twist is moreover advancing longer-term alternatives in agenda abstracts accumulator in DNA and biologics biologic discovery. Twist makes articles to be used past abounding industries together with healthcare, automated chemical compounds, agronomics and bookish analysis.

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All Twist Bioscience articles are Evaluation Use Solely.

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Authorized Discover Concerning Ahead-Trying Statements

This columnist absolution comprises superior statements. All statements added than statements of absolute info impartial herein are superior statements absorption the accepted conduct and expectations of administration fabricated pursuant to the protected anchorage accoutrement of the Personal Securities Litigation Reform Act of 1995. Such superior statements soak up accepted and alien dangers, uncertainties, and added necessary elements which will account Twist Bioscience’s absolute outcomes, efficiency, or achievements to be materially altered from any approaching outcomes, efficiency, or achievements bidding or adumbrated by the superior statements. Such dangers and uncertainties embody, amid others, the dangers and uncertainties of the adeptness to attract new barter and soak up and abound gross sales from absolute prospects; dangers and uncertainties of quickly alteration applied sciences and all-encompassing antagonism in constructed evaluation might accomplish the articles Twist Bioscience is creating anachronistic or non-competitive; uncertainties of the assimilation of a cogent buyer; dangers of third affair claims alleging contravention of patents and proprietary rights or gluttonous to invalidate Twist Bioscience’s patents or proprietary rights; and the accident that Twist Bioscience’s proprietary rights could also be bereft to guarantee its applied sciences. For a added description of the dangers and uncertainties that might account absolute after-effects to change from these bidding in these superior statements, as able-bodied as dangers apropos to Twist Bioscience’s enterprise usually, see Twist Bioscience’s accident elements set alternating in Twist Bioscience’s Quarterly Report on Type 10-Q filed with the Securities and Trade Fee on August 9, 2019. Any superior statements impartial on this columnist absolution allege alone as of the date hereof, and Twist Bioscience precisely disclaims any obligation to amend any superior assertion, whether or not as a aftereffect of recent data, approaching contest or in any other case.

View antecedent adaptation on businesswire.com: https://www.businesswire.com/information/house/20191016005291/en/

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